Endocrine Abstracts

Nitric oxide (NO) is a ubiquitous gaseous signaling molecule, many of whose physiological roles are mediated through activation of the soluble guanylate cyclase. At physiological concentrations, NO also inhibits the mitochondrial enzyme cytochrome c oxidase (complex IV) in competition with oxygen. We have suggested that the interplay between these two gases allows complex IV to act as an oxygen sensor in cells and have shown that endogenous NO modulates oxygen consumption unde...